Top latest Five ceesdekker.net Urban news
Top latest Five ceesdekker.net Urban news
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Working with solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our research pursuits contain:
It was only from the 1990s while, when nanotechnology had State-of-the-art to a stage where solitary molecules may very well be manipulated, that the initial experimental products began to look.
Back again in 1991, Sumio Iijima on the NEC Company had documented the synthesis of carbon nanotubes. Band framework calculations proposed that these nanotubes could show metallic band conduction. This may be a big advantage over the conducting polymers we had explored, which were, in fact, disordered semiconductors offering merely variable-range hopping conductivity.
2007, initially genuine-time detection of strand Trade in homologous recombination by RecA; discovery of the reduced persistence size of finishes of microtubules; and fixed the mechanism of biosensing with carbon nanotubes
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and very first at any time examine with the dynamics DNA supercoils and the discovery of supercoil hopping
Immediate immobilization of native yeast iso-one cytochrome c on bare gold: quick electron relay to redox enzymes and zeptomole protein-movie voltammetry
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with research from DNA supercoiling experiments of nucleosomes and DNA repair service proteins to DNA translocation by way of nanopores. Not too long ago his study has centered on finding out cell division with microbes on chip, even though his final interest is from the route of noticing synthetic cells.
2000, discovery that nanotubes can have extraordinary massive current densities; settled the controversial challenge of electronic transportation through DNA molecules by measurements of insulating habits at The one molecule level; and demonstration of an AFM procedure for single-molecule manipulation of nanotubes
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Resolving the phase measurement in condensin-driven DNA loop extrusion identifies ATP binding because the stage-producing procedure
In 1993 he was appointed as Associate Professor at Delft College of Technological innovation. In the mid-nineties Dekker and his staff achieved good results with the invention of your electronic Homes of carbon nanotubes, the 1st one-molecule transistor as well as other nanoscience.
‘That fears the synthetic cell, as Element of the Dutch BaSyC initiative. Craig Venter looked top rated-down in These times and discovered about five hundred genes that happen to be minimally required for the performing cell. We want to seem base-up: how do we transfer from the few molecules to a complete biological procedure?
2005, discovery with the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of prolonged-range conformational alterations in Mre11/DNA repair complexes; and 1st drive cees dekker measurements on the DNA molecule in a very nanopore
‘I am driven by speculate and thoughts. On a material level I locate solutions in physics, but I practical experience my deepest contentment with God. That religion also drives my science and how I cope with folks.